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CNRS
Molecular virology
Paris (France)

Current status: Associate Member - Application: 2008, 05 April - Admittance: 2008, 25 April

General data
Organization Group name Group size Web site Address Country Status
CNRS Molecular virology 4 permanent
4 temporary
web site Virologie moléculaire
Institut Jacques Monod
CNRS-Université Paris 7
2 place Jussieu
75251 Paris cedex 05
France
France Research unit group
Staff of the group
Interests of the group
The aim of our group is to elucidate the molecular basis of viral replication. We are currently studying TYMV (turnip yellow mosaic virus), a plant virus that is extremely well characterized at the molecular level and is one of the few viruses able to infect the model plant Arabidopsis thaliana.
Using a combination of molecular, cellular, biochemical and genetic approaches, we are currently studying the molecular mechanisms controlling the assembly, membrane targeting and regulation of TYMV replication complexes, as well as working toward the identification of the cellular proteins participating in viral replication.
This should give us a better understanding of the molecular basis of viral replication, a prerequisite for the development of new antiviral strategies.
Publications
  • PROD'HOMME, D., JAKUBIEC, A., TOURNIER, V., DRUGEON, G. and JUPIN, I. (2003)
    Targeting of the turnip yellow mosaic virus 66K replication protein to the chloroplast envelope is mediated by the 140K protein.
    Journal of Virology 77, 9124-9135.
  • JAKUBIEC, A., NOTAISE, J., TOURNIER, V., HERICOURT, F., BLOCK, M.A., DRUGEON, G., van AELST, L. and JUPIN, I. (2004)
    Assembly of Turnip yellow mosaic virus replication complexes : interaction between the proteinase and polymerase domains of the replication proteins.
    Journal of Virology 78, 7945-7957
  • JAKUBIEC, A., TOURNIER, V., DRUGEON, G., PFLIEGER, S., CAMBORDE, L., VINH, J., HERICOURT, F., REDEKER, V. and JUPIN, I. (2006)
    Phosphorylation of viral RNA-dependent RNA polymerase and its role in replication of a plus-strand RNA virus.
    Journal of Biological Chemistry 281, 21236-21249.
  • CAMBORDE, L., TOURNIER, V., NOIZET, M. & JUPIN, I. (2007)
    A TYMV infection system in Arabidopsis suspension cell culture.
    FEBS Letters 581, 337-341.
  • JAKUBIEC, A., DRUGEON, G., CAMBORDE, L. & JUPIN, I. (2007)
    Proteolytic processing of TYMV replication proteins and functional impact on infectivity.
    Journal of Virology 81,11402-11412.